Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling.

ABSTRACT: Certain fish and amphibians regenerate entire fins and limbs after amputation, whereas such potential is absent in birds and limited in mammals to digit tips [1, 2]. Additionally, regenerative success can change during life stages. Anuran tadpoles gradually lose the capacity to regenerate limbs [3, 4], and digit regeneration occurs more effectively in fetal mice and human children than adults [5-8]. Little is known about mechanisms that control regenerative capacity. Here, we identify an unexpected difference between male and female zebrafish in the regenerative potential of a major appendage. Males display regenerative defects in amputated pectoral fins, caused by impaired blastemal proliferation. This regenerative failure emerges after sexual maturity, is mimicked in androgen-treated fem

SUBMITTER: Nachtrab G 

PROVIDER: S-EPMC3236601 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature