Ontology highlight
ABSTRACT:
SUBMITTER: Lin LF
PROVIDER: S-EPMC3237114 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Cancer research 20091208 1
The BRCA1-interacted transcriptional repressor ZBRK1 has been associated with antiangiogenesis, but direct evidence of a tumor suppressor role has been lacking. In this study, we provide evidence of such a role in cervical carcinoma. ZBRK1 levels in cervical tumor cells were significantly lower than in normal cervical epithelial cells. In HeLa cervical cancer cells, enforced expression inhibited malignant growth, invasion, and metastasis in a variety of in vitro and in vivo assays. Expression of ...[more]