Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish.

ABSTRACT: Bisphenol-A is an important environmental contaminant due to the increased early-life exposure that may pose significant health-risks to various organisms including humans. This study aimed to use zebrafish as a toxicogenomic model to capture transcriptomic and phenotypic changes for inference of signaling pathways, biological processes, physiological systems and identify potential biomarker genes that are affected by early-life exposure to bisphenol-A. Phenotypic analysis using wild-type zebrafish larvae revealed BPA early-life exposure toxicity caused cardiac edema, cranio-facial abnormality, failure of swimbladder inflation and poor tactile response. Fluorescent imaging analysis using three transgenic lines revealed suppressed neuron branching from the spinal cord, abnormal development

SUBMITTER: Lam SH 

PROVIDER: S-EPMC3237442 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature