Partner-aware prediction of interacting residues in protein-protein complexes from sequence data.

ABSTRACT: Computational prediction of residues that participate in protein-protein interactions is a difficult task, and state of the art methods have shown only limited success in this arena. One possible problem with these methods is that they try to predict interacting residues without incorporating information about the partner protein, although it is unclear how much partner information could enhance prediction performance. To address this issue, the two following comparisons are of crucial significance: (a) comparison between the predictability of inter-protein residue pairs, i.e., predicting exactly which residue pairs interact with each other given two protein sequences; this can be achieved by either combining conventional single-protein predictions or making predictions using a new model t

SUBMITTER: Ahmad S 

PROVIDER: S-EPMC3237601 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature