Replication of a genome-wide association study of birth weight in preterm neonates.

ABSTRACT:

Objective

To examine associations between rs9883204 in ADCY5 and rs900400 near LEKR1 and CCNL1 with birth weight in a preterm population. Both markers were associated with birth weight in a term population in a recent genome-wide association study of Freathy et al.

Study design

A meta-analysis of mother and infant samples was performed for associations of rs900400 and rs9883204 with birth weight in 393 families from the US, 265 families from Argentina, and 735 mother-infant pairs from Denmark. Z-scores adjusted for infant sex and gestational age were generated for each population separately and regressed on allele counts. Association evidence was combined across sites by inverse-variance weighted meta-analysis.

Results

Each additional C allele of rs900400 (LEKR1/CCNL1

SUBMITTER: Ryckman KK 

PROVIDER: S-EPMC3237813 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature