Effects of vitamin A and D receptor gene polymorphisms/haplotypes on immune responses to measles vaccine.

ABSTRACT:

Objective

Vitamins A and D, and their receptors, are important regulators of the immune system, including vaccine immune response. We assessed the association between polymorphisms in the vitamin A receptors [retinoic acid receptor α, retinoic acid receptor β (RARB), and retinoic acid receptor γ] and vitamin D receptor (VDR)/retinoid X receptor α (RXRA) genes and interindividual variations in immune responses after two doses of measles vaccine in 745 children.

Methods

Using a tag single nucleotide polymorphism (SNP) approach, we genotyped 745 healthy children for the 391 polymorphisms in vitamin A receptor and VDR genes.

Results

The RARB haplotype (rs6800566/rs6550976/rs9834818) was significantly associated with variations in both measles antibody (global, P=0.013) an

SUBMITTER: Ovsyannikova IG 

PROVIDER: S-EPMC3237827 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature