Effects of chronic transfusions on abdominal sonographic abnormalities in children with sickle cell anemia.

ABSTRACT:

Objective

To assess the effects of chronic erythrocyte transfusions on prevalence of sonographic incidence of organ damage in children with sickle cell anemia (SCA).

Study design

Children (N=148; mean age, 13.0 years) with SCA, receiving chronic transfusions (average, 7 years), underwent abdominal sonography at 25 institutions. After central imaging review, spleen, liver, and kidney measurements were compared with published normal values. Potential relations between ultrasound, clinical, and laboratory data were explored via analysis of variance, Student t test, and Cochran-Mantel-Haenzel tests of non-zero correlation.

Results

Average spleen length was similar to normal children, but over one-third had spleen volumes >300 mL, 15 had previous splenectomy for splenomega

SUBMITTER: McCarville MB 

PROVIDER: S-EPMC3237893 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature