The effect of short-term hypoxic exposure on metabolic gene expression.

ABSTRACT: The long-term effect of hypoxia is to decrease both the production and use of ATP and thus decrease the reliance on mitochondrial oxidative energy production. Yet, recent studies include more immediate affects of hypoxia on gene expression and these data suggest the maintenance of mitochondrial function. To better understand the short-term physiological response to hypoxia, we quantified metabolic mRNA expression in the heart ventricles and livers of the teleost fish Fundulus grandis exposed to partial oxygen pressure of 2.8 kPa (-13.5% air saturation).Twenty-eight individuals from a single population were exposed to hypoxia for 0, 4, 8, 12, 24, 48, and 96  hr. Liver and cardiac tissues were sampled from the same individuals at 0-48  hr. At 96  hr, only cardiac tissue was assayed. Gene exp

SUBMITTER: Everett MV 

PROVIDER: S-EPMC3237964 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature