Molecular nanofibers of olsalazine form supramolecular hydrogels for reductive release of an anti-inflammatory agent.

ABSTRACT: Conjugation of tripeptide derivatives with olsalazine, a clinically used anti-inflammatory prodrug, yields small molecules that self-assemble in water to form supramolecular hydrogels that undergo a gel-to-sol phase transition upon reduction, resulting in the controlled release of 5-aminosalicylic acid as the anti-inflammatory agent. This methodology will ultimately lead to new biomaterials for site-specific drug delivery.

SUBMITTER: Li X 

PROVIDER: S-EPMC3238101 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature