Understanding network concepts in modules.

ABSTRACT:

Background

Network concepts are increasingly used in biology and genetics. For example, the clustering coefficient has been used to understand network architecture; the connectivity (also known as degree) has been used to screen for cancer targets; and the topological overlap matrix has been used to define modules and to annotate genes. Dozens of potentially useful network concepts are known from graph theory.

Results

Here we study network concepts in special types of networks, which we refer to as approximately factorizable networks. In these networks, the pairwise connection strength (adjacency) between 2 network nodes can be factored into node specific contributions, named node 'conformity'. The node conformity turns out to be highly related to the connectivity. To provid

SUBMITTER: Dong J 

PROVIDER: S-EPMC3238286 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature