Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk.

ABSTRACT:

Objective

The insulin-like growth factor (IGF) pathway plays a critical role in the growth and development of the uterus and is believed to function as a mediator of steroid hormone actions in the endometrium. The local expression of genes encoding IGFs and IGF-binding proteins (IGFBPs) is important in determining IGF bioactivity in the uterus. Genetic variation in key genes within the IGF pathway may influence the rate of cellular proliferation and differentiation in the uterus and ultimately affect the risk of endometrial cancer. Our hypothesis is that variant alleles in key genes involved in the IGF pathway will influence the development of endometrial cancer.

Methods

We conducted a case-control study nested within the Nurses' Health Study (NHS) and the Women's Health Stu

SUBMITTER: McGrath M 

PROVIDER: S-EPMC3238452 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature