Large prospective investigation of meat intake, related mutagens, and risk of renal cell carcinoma.

ABSTRACT:

Background

The evidence for meat intake and renal cell carcinoma (RCC) risk is inconsistent. Mutagens related to meat cooking and processing, and variation by RCC subtype may be important to consider.

Objective

In a large US cohort, we prospectively investigated intake of meat and meat-related compounds in relation to risk of RCC, as well as clear cell and papillary RCC histologic subtypes.

Design

Study participants (492,186) completed a detailed dietary assessment linked to a database of heme iron, heterocyclic amines (HCA), polycyclic aromatic hydrocarbons (PAHs), nitrate, and nitrite concentrations in cooked and processed meats. Over 9 (mean) y of follow-up, we identified 1814 cases of RCC (498 clear cell and 115 papillary adenocarcinomas). HRs and 95% CIs were est

SUBMITTER: Daniel CR 

PROVIDER: S-EPMC3238458 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature