Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults.

ABSTRACT:

Background

Vitamin D receptor (VDR) and the megalin gene polymorphism's link with longitudinal cognitive change remains unclear.

Objective

The associations of single nucleotide polymorphisms (SNPs) for VDR [rs11568820 (CdX-2:T/C), rs1544410 (BsmI:G/A), rs7975232 (ApaI:A/C), rs731236 (TaqI:G/A)], and Megalin (rs3755166:G/A; rs2075252:C/T; rs4668123:C/T) genes with longitudinal cognitive performance changes were examined.

Design

Data from 702 non-Hispanic white participants in the Baltimore Longitudinal Study of Aging were used. Longitudinal annual rates of cognitive change (LARCCs) between age 50 y and the individual mean follow-up age were predicted with linear mixed models by using all cognitive score time points (prediction I) or time points before dementia onset (p

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC3238459 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature