Cytokine disturbances in systemic lupus erythematosus.
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ABSTRACT:
SUBMITTER: Jacob N
PROVIDER: S-EPMC3239336 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Cytokine disturbances in systemic lupus erythematosus.
Arthritis research & therapy 20110706 4
The pathogenesis of systemic lupus erythematosus (SLE) is complex, and the resulting disease manifestations are heterogeneous. Cytokine dysregulation is pervasive, and their protein and gene expression profiles may serve as markers of disease activity and severity. Importantly, biologic agents that target specific cytokines may represent novel therapies for SLE. Four cytokines (IL-6, TNFα, IFNα, and BLyS) are being evaluated as therapeutic targets in SLE. The present review will examine the role ...[more]
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