Large-scale screening of a targeted Enterococcus faecalis mutant library identifies envelope fitness factors.

ABSTRACT: Spread of antibiotic resistance among bacteria responsible for nosocomial and community-acquired infections urges for novel therapeutic or prophylactic targets and for innovative pathogen-specific antibacterial compounds. Major challenges are posed by opportunistic pathogens belonging to the low GC% gram-positive bacteria. Among those, Enterococcus faecalis is a leading cause of hospital-acquired infections associated with life-threatening issues and increased hospital costs. To better understand the molecular properties of enterococci that may be required for virulence, and that may explain the emergence of these bacteria in nosocomial infections, we performed the first large-scale functional analysis of E. faecalis V583, the first vancomycin-resistant isolate from a human bloodstream inf

SUBMITTER: Rigottier-Gois L 

PROVIDER: S-EPMC3240637 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature