Insulin-like growth factor-1 receptor is regulated by microRNA-133 during skeletal myogenesis.

ABSTRACT:

Background

The insulin-like growth factor (IGF) signaling pathway has long been established as playing critical roles in skeletal muscle development. However, the underlying regulatory mechanism is poorly understood. Recently, a large family of small RNAs, named microRNAs (miRNAs), has been identified as key regulators for many developmental processes. Because miRNAs participate in the regulation of various signaling pathways, we hypothesized that miRNAs may be involved in the regulation of IGF signaling in skeletal myogenesis.

Methodology/principal findings

In the present study, we determined that the cell-surface receptor IGF-1R is directly regulated by a muscle-specific miRNA, microRNA-133 (miR-133). A conserved and functional binding site for miR-133 was identified in th

SUBMITTER: Huang MB 

PROVIDER: S-EPMC3240640 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature