Clinicopathologic and gene expression parameters predict liver cancer prognosis.

ABSTRACT:

Background

The prognosis of hepatocellular carcinoma (HCC) varies following surgical resection and the large variation remains largely unexplained. Studies have revealed the ability of clinicopathologic parameters and gene expression to predict HCC prognosis. However, there has been little systematic effort to compare the performance of these two types of predictors or combine them in a comprehensive model.

Methods

Tumor and adjacent non-tumor liver tissues were collected from 272 ethnic Chinese HCC patients who received curative surgery. We combined clinicopathologic parameters and gene expression data (from both tissue types) in predicting HCC prognosis. Cross-validation and independent studies were employed to assess prediction.

Results

HCC prognosis was significan

SUBMITTER: Hao K 

PROVIDER: S-EPMC3240666 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature