Laminar expression of ephrin-A2 in primary somatosensory cortex of postnatal rats.

ABSTRACT: Several Eph receptors, prominently EphA4 and EphA7, and their corresponding ligands are known to influence neocortical development, including topographic sorting of thalamocortical axons within primary somatosensory cortex (SI). This study investigated postnatal expression of a ligand that can bind to these receptors, ephrin-A2. Quantitative methods revealed that expression of ephrin-A2 mRNA in SI reached maximum levels on postnatal day (P) 4 and dropped thereafter to background by P18. Ephrin-A2 mRNA expression assessed by in situ hybridization qualitatively revealed a similar time course and localized the expression pattern primarily in two broad laminae in SI, comprising the supragranular and infragranular layers, and with additional expression in the subplate. This expression pattern w

SUBMITTER: Kenmuir CL 

PROVIDER: S-EPMC3240726 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature