Lamotrigine monotherapy for newly diagnosed typical absence seizures in children.

ABSTRACT:

Purpose

To evaluate the efficacy, tolerability, and effects on behavior and psychosocial functioning of lamotrigine monotherapy in children with newly diagnosed typical absence seizures.

Patients and methods

Children meeting enrollment criteria (n=54) received a confirmatory 24-h ambulatory electroencephalogram (EEG) and then entered a Escalation Phase of up to 20-weeks during which lamotrigine was titrated until seizures were controlled or maximum dose (10.2mg/kg) was reached. Seizure freedom was assessed by diary review and clinic hyperventilation (clinic HV) and then confirmed by EEG with hyperventilation (HV/EEG). Patients who maintained seizure freedom for two consecutive weekly visits were entered into the Maintenance Phase (n=30). Diary, clinic HV, and HV/EEG data wer

SUBMITTER: Holmes GL 

PROVIDER: S-EPMC3240743 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature