Everolimus and long acting octreotide as a volume reducing treatment of polycystic livers (ELATE): study protocol for a randomized controlled trial.

ABSTRACT:

Background

Polycystic liver disease (PLD) is defined as having more than 20 liver cysts and can present as a severe and disabling condition. Most symptoms are caused by the mass effect of the liver size and include abdominal pain and distension. The somatostatin analogues octreotide and lanreotide have proven to reduce polycystic liver volume. mTOR inhibitors such as everolimus inhibit cell proliferation and might thereby reduce growth of liver cysts. This trial aims to assess the benefit of combination therapy of everolimus and octreotide compared to octreotide monotherapy. In this study we present the structure of the trial and the characteristics of the included patients.

Methods/design

This is a randomized open-label clinical trial comparing the effect of 12 months of ev

SUBMITTER: Chrispijn M 

PROVIDER: S-EPMC3240834 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature