Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies.

ABSTRACT:

Objectives

The aim of this study was to evaluate whether coronary heart disease (CHD)-susceptibility loci identified by genome-wide association studies of the general population also contribute to CHD in type 2 diabetes.

Background

No study has examined the effects of these genetic variants on CHD in diabetic patients.

Methods

We genotyped 15 genetic markers of 12 loci in 3 studies of diabetic patients: the prospective Nurses' Health Study (309 CHD cases, and 544 control subjects) and Health Professional Follow-up Study (345 CHD cases, and 451 control subjects) and the cross-sectional Joslin Heart Study (422 CHD cases, and 435 control subjects).

Results

Five single-nucleotide polymorphisms, rs4977574 (CDKN2A/2B), rs12526453 (PHACTR1), rs646776 (CELSR2-PSRC1-SOR

SUBMITTER: Qi L 

PROVIDER: S-EPMC3240896 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature