Experimental designs for robust detection of effects in genome-wide case-control studies.

ABSTRACT: In genome-wide association studies hundreds of thousands of loci are scanned in thousands of cases and controls, with the goal of identifying genomic loci underpinning disease. This is a challenging statistical problem requiring strong evidence. Only a small proportion of the heritability of common diseases has so far been explained. This "dark matter of the genome" is a subject of much discussion. It is critical to have experimental design criteria that ensure that associations between genomic loci and phenotypes are robustly detected. To ensure associations are robustly detected we require good power (e.g., 0.8) and sufficiently strong evidence [i.e., a high Bayes factor (e.g., 10(6), meaning the data are 1 million times more likely if the association is real than if there is no associat

SUBMITTER: Ball RD 

PROVIDER: S-EPMC3241427 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature