A computational model of cellular mechanisms of temporal coding in the medial geniculate body (MGB).

ABSTRACT: Acoustic stimuli are often represented in the early auditory pathway as patterns of neural activity synchronized to time-varying features. This phase-locking predominates until the level of the medial geniculate body (MGB), where previous studies have identified two main, largely segregated response types: Stimulus-synchronized responses faithfully preserve the temporal coding from its afferent inputs, and Non-synchronized responses, which are not phase locked to the inputs, represent changes in temporal modulation by a rate code. The cellular mechanisms underlying this transformation from phase-locked to rate code are not well understood. We use a computational model of a MGB thalamocortical neuron to test the hypothesis that these response classes arise from inferior colliculus (IC) exci

SUBMITTER: Rabang CF 

PROVIDER: S-EPMC3241713 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature