Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk.

ABSTRACT: The pathogenesis of intracranial aneurysm (IA) formation and rupture is complex, with significant contribution from genetic factors. We previously reported genome-wide association studies based on European discovery and Japanese replication cohorts of 5,891 cases and 14,181 controls that identified five disease-related loci. These studies were based on testing replication of genomic regions that contained SNPs with posterior probability of association (PPA) greater than 0.5 in the discovery cohort. To identify additional IA risk loci, we pursued 14 loci with PPAs in the discovery cohort between 0.1 and 0.5. Twenty-five SNPs from these loci were genotyped using two independent Japanese cohorts, and the results from discovery and replication cohorts were combined by meta-analysis. The result

SUBMITTER: Yasuno K 

PROVIDER: S-EPMC3241810 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature