Listeria monocytogenes tyrosine phosphatases affect wall teichoic acid composition and phage resistance.

ABSTRACT: Tyrosine phosphatase (PTP)-like proteins exist in many bacteria and are segregated into two major groups: low molecular weight and conventional. The latter group also has activity as phosphoinositide phosphatases. These two kinds of PTP are suggested to be involved in many aspects of bacterial physiology including stress response, DNA binding proteins, virulence, and capsule/cell wall production. By annotation, Listeria monocytogenes possesses two potential low molecular weight and two conventional PTPs. Using L. monocytogenes wild-type (WT) strain 10403S, we have created an in-frame deletion mutant lacking all four PTPs, as well as four additional complemented strains harboring each of the PTPs. No major physiological differences were observed between the WT and the mutant lacking all fou

SUBMITTER: Nir-Paz R 

PROVIDER: S-EPMC3241885 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature