Genome-wide association study of comorbid depressive syndrome and alcohol dependence.

ABSTRACT:

Objective

Depression and alcohol dependence (AD) are common psychiatric disorders that often co-occur. Both disorders are genetically influenced, with heritability estimates in the range of 35-60%. In addition, evidence from twin studies suggests that AD and depression are genetically correlated. Herein, we report results from a genome-wide association study of a comorbid phenotype, in which cases meet the Diagnostic and Statistical Manual of Mental Disorders-IV symptom threshold for major depressive symptomatology and the Diagnostic and Statistical Manual of Mental Disorders-IV criteria for AD.

Methods

Samples (N=467 cases and N=407 controls) were of European-American descent and were genotyped using the Illumina Human 1M BeadChip array.

Results

Although no single-nu

SUBMITTER: Edwards AC 

PROVIDER: S-EPMC3241912 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature