Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures.

ABSTRACT: Cardiac muscle is equipped with intricate intrinsic mechanisms to regulate adaptive remodeling. Recent and extensive experimental findings powered by novel strategies for screening protein-protein interactions, improved imaging technologies, and versatile transgenic mouse methodologies reveal that Z disks and titin filaments possess unexpectedly complicated sensory and modulatory mechanisms for signal reception and transduction. These mechanisms employ molecules such as muscle-enriched LIM domain proteins, PDZ-LIM domain proteins, myozenin gene family members, titin-associated ankyrin repeat family proteins, and muscle-specific ring finger proteins, which have been identified as potential molecular sensor components. Moreover, classic transmembrane signaling processes, including mitogen-ac

SUBMITTER: Hoshijima M 

PROVIDER: S-EPMC3241960 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature