Androgen receptor genotypes predict response to endocrine treatment in breast cancer patients.

ABSTRACT:

Background

The androgen receptor (AR) is frequently expressed in breast cancers. The AR genotype may affect disease-free survival and response to endocrine therapy.

Methods

In all, 634 women undergoing breast cancer surgery between 2002 and 2008 were followed until 30 June 2010. Six haplotype-tagging single-nucleotide polymorphisms in the AR, and the resulting AR diplotypes, were examined in relation to breast cancer patient characteristics, tumour characteristics, disease-free survival, and response to endocrine treatment.

Results

Five common AR diplotypes were found. Seventeen rare variants were combined into a composite group. The resulting six AR diplotype groups were clustered into two subgroups, groups A (n=128) and B (n=499), with three diplotypes in each. Pati

SUBMITTER: Lundin KB 

PROVIDER: S-EPMC3242599 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature