TYRP1 mRNA expression in melanoma metastases correlates with clinical outcome.

ABSTRACT:

Background

Clinical outcome of patients with high-risk melanoma cannot be reliably predicted on the basis of classical histopathological examination. Our study aimed to determine in melanoma metastases a gene expression profile associated with patient survival, and to identify and validate marker(s) of poor clinical outcome.

Methods

Skin and lymph node metastases from melanoma patients (training population) were used to identify candidate prognostic marker(s) based on DNA microarray analysis. Additional skin metastases (validation population) were used to assess the prognostic value of the first ranked gene by real-time PCR.

Results

We performed microarray analysis in the training population and generated a list of 278 probe sets associated with a shorter survival. We

SUBMITTER: Journe F 

PROVIDER: S-EPMC3242608 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature