Identification and functional analysis of Joka2, a tobacco member of the family of selective autophagy cargo receptors.

ABSTRACT: Two main mechanisms of protein turnover exist in eukaryotic cells: the ubiquitin-proteasome system and the autophagy-lysosomal pathway. Autophagy is an emerging important constituent of many physiological and pathological processes, such as response to nutrient deficiency, programmed cell death and innate immune response. In mammalian cells the selectivity of autophagy is ensured by the presence of cargo receptors, such as p62/SQSTM1 and NBR1, responsible for sequestration of the ubiquitinated proteins. In plants no selective cargo receptors have been identified yet. The present report indicates that structural and functional homologs of p62 and NBR1 proteins exist in plants. The tobacco protein, named Joka2, has been identified in yeast two-hybrid search as a binding partner of a small co

SUBMITTER: Zientara-Rytter K 

PROVIDER: S-EPMC3242614 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature