Genome-wide high-density SNP linkage search for glioma susceptibility loci: results from the Gliogene Consortium.

ABSTRACT: Gliomas, which generally have a poor prognosis, are the most common primary malignant brain tumors in adults. Recent genome-wide association studies have shown that inherited susceptibility plays a role in the development of glioma. Although first-degree relatives of patients exhibit a two-fold increased risk of glioma, the search for susceptibility loci in familial forms of the disease has been challenging because the disease is relatively rare, fatal, and heterogeneous, making it difficult to collect sufficient biosamples from families for statistical power. To address this challenge, the Genetic Epidemiology of Glioma International Consortium (Gliogene) was formed to collect DNA samples from families with two or more cases of histologically confirmed glioma. In this study, we present re

SUBMITTER: Shete S 

PROVIDER: S-EPMC3242820 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature