Efficacy of selective mineralocorticoid and glucocorticoid agonists in canine septic shock.

ABSTRACT:

Objective

Corticosteroid regimens that stimulate both mineralocorticoid and glucocorticoid pathways consistently reverse vasopressor-dependent hypotension in septic shock but have variable effects on survival. The objective of this study was to determine whether exogenous mineralocorticoid and glucocorticoid treatments have distinct effects and whether the timing of administration alters their effects in septic shock. DESIGN, SETTING, SUBJECTS, AND INTERVENTIONS: Desoxycorticosterone, a selective mineralocorticoid agonist; dexamethasone, a selective glucocorticoid agonist; and placebo were administered either several days before (prophylactic) or immediately after (therapeutic) infectious challenge and continued for 96 hrs in 74 canines with staphylococcal pneumonia.

Measurement

SUBMITTER: Hicks CW 

PROVIDER: S-EPMC3242885 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature