Population pharmacokinetics of ceftriaxone in critically ill septic patients: a reappraisal.

ABSTRACT:

Aims

To investigate the population pharmacokinetics of ceftriaxone in critically ill patients suffering from sepsis, severe sepsis or septic shock.

Methods

Blood samples were collected at preselected times in 54 adult patients suffering from sepsis, severe sepsis or septic shock in order to determine ceftriaxone concentrations using high-performance liquid chromatography-ultraviolet detection. The pharmacokinetics of ceftriaxone were assessed on two separate occasions for each patient: on the second day of ceftriaxone therapy and 48 h after catecholamine withdrawal in patients with septic shock, or on the fifth day in patients with sepsis. The population pharmacokinetics of ceftriaxone were studied using nonlinear mixed effects modelling.

Results

The population estima

SUBMITTER: Garot D 

PROVIDER: S-EPMC3243010 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature