Prognostic and predictive value of a malignancy-risk gene signature in early-stage non-small cell lung cancer.

ABSTRACT:

Background

The malignancy-risk gene signature is composed of numerous proliferative genes and has been applied to predict breast cancer risk. We hypothesized that the malignancy-risk gene signature has prognostic and predictive value for early-stage non-small cell lung cancer (NSCLC) patients.

Methods

The ability of the malignancy-risk gene signature to predict overall survival (OS) of early-stage NSCLC patients was tested using a large NSCLC microarray dataset from the Director's Challenge Consortium (n = 442) and two independent NSCLC microarray datasets (n = 117 and 133, for the GSE13213 and GSE14814 datasets, respectively). An overall malignancy-risk score was generated by principal component analysis to determine the prognostic and predictive value of the signature. An

SUBMITTER: Chen DT 

PROVIDER: S-EPMC3243673 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature