Activation of the innate immune response against DENV in normal non-transformed human fibroblasts.

ABSTRACT:

Background

When mosquitoes infected with DENV are feeding, the proboscis must traverse the epidermis several times ("probing") before reaching a blood vessel in the dermis. During this process, the salivary glands release the virus, which is likely to interact first with cells of the various epidermal and dermal layers, cells which could be physiologically relevant to DENV infection and replication in humans. However, important questions are whether more abundant non-hematopoietic cells such as fibroblasts become infected, and whether they play any role in antiviral innate immunity in the very early stages of infection, or even if they might be used by DENV as primary replication cells.

Methodology/principal findings

Fibroblasts freshly released from healthy skin and infecte

SUBMITTER: Bustos-Arriaga J 

PROVIDER: S-EPMC3243703 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature