Design and synthesis of a new class of membrane-permeable triazaborolopyridinium fluorescent probes.

ABSTRACT: A new class of fluorescent triazaborolopyridinium compounds was synthesized from hydrazones of 2-hydrazinylpyridine (HPY) and evaluated as potential dyes for live-cell imaging applications. The HPY dyes are small, their absorption/emission properties are tunable through variation of pyridyl or hydrazone substituents, and they offer favorable photophysical characteristics featuring large Stokes shifts and general insensitivity to solvent or pH. The stability, neutral charge, cell membrane permeability, and favorable relative influences on the water solubility of HPY conjugates are complementary to existing fluorescent dyes and offer advantages for the development of receptor-targeted small-molecule probes. This potential was assessed through the development of a new class of cysteine-derive

SUBMITTER: Hapuarachchige S 

PROVIDER: S-EPMC3244355 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature