Impact of more than a decade of pneumococcal conjugate vaccine use on carriage and invasive potential in Native American communities.

ABSTRACT:

Background

We assessed the impact of 12 years of pneumococcal conjugate vaccine (PCV7) use on pneumococcal nasopharyngeal carriage and serotype-specific invasive disease potential among Native Americans.

Methods

Families were enrolled in a carriage study from 2006 to 2008; nasopharyngeal specimens and risk factor information were collected monthly for 7 visits. Pneumococcal carriage prevalence was compared with that before (1998-2000) and during (2001-2002) PCV7 introduction. We compared invasive disease incidence and carriage prevalence before and after PCV7 introduction to estimate changes in serotype-specific invasive potential.

Results

We enrolled 1077 subjects from 302 households. There was an absolute reduction in carriage prevalence of 8.0% (95% confidence inte

SUBMITTER: Scott JR 

PROVIDER: S-EPMC3244367 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature