Statistical epistasis and functional brain imaging support a role of voltage-gated potassium channels in human memory.

ABSTRACT: Despite the current progress in high-throughput, dense genome scans, a major portion of complex traits' heritability still remains unexplained, a phenomenon commonly termed "missing heritability." The negligence of analytical approaches accounting for gene-gene interaction effects, such as statistical epistasis, is probably central to this phenomenon. Here we performed a comprehensive two-way SNP interaction analysis of human episodic memory, which is a heritable complex trait, and focused on 120 genes known to show differential, memory-related expression patterns in rat hippocampus. Functional magnetic resonance imaging was also used to capture genotype-dependent differences in memory-related brain activity. A significant, episodic memory-related interaction between two markers located in

SUBMITTER: Heck A 

PROVIDER: S-EPMC3244442 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature