Myocilin mutations among POAG patients from two populations of Tamil Nadu, South India, a comparative analysis.

ABSTRACT:

Purpose

Primary open angle glaucoma (POAG) is the most common type of glaucoma. Among the POAG genes identified so far, myocilin (MYOC) is the most frequently mutated gene in POAG patients worldwide. The MYOC Gln48His mutation is unique among Indian POAG patients. This mutation has not been observed in some populations within India and in other populations worldwide. The objectives of this work were to characterize and compare the mutation spectrum among POAG patients from two places of South India and identify the occurrence and prevalence of Gln48His mutation in our study populations.

Methods

One hundred-one (101) POAG patients from Chennai, South India were recruited for the study. Earlier, 100 patients from the southernmost part of India, Kanyakumari district, were scree

SUBMITTER: Rose R 

PROVIDER: S-EPMC3244482 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature