Parent-of-origin effects of FAS and PDLIM1 in attention-deficit/hyperactivity disorder.

ABSTRACT:

Background

Previous studies have suggested that there may be a parent-of-origin effect for attention-deficit/hyperactivity disorder(ADHD) candidate genes. The objective of the present study was to investigate parent-of-origin effects using a genome-wide association analysis of the International Multicentre ADHD Genetics (IMAGE) study sample.

Methods

Family-based association analysis for ADHD using 846 ADHD probands and their parents was performed using the PLINK program, and parent-of-origin effects were studied using a Z score for the difference in paternal versus maternal odds ratios.

Results

We identified 44 single nucleotide polymorphisms (SNPs) showing parent-of-origin effects at a significance level of p < 0.001. The most significant SNP, rs7614907, is at positi

SUBMITTER: Wang KS 

PROVIDER: S-EPMC3244498 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature