Propofol disrupts functional interactions between sensory and high-order processing of auditory verbal memory.

ABSTRACT: Current theories suggest that disrupting cortical information integration may account for the mechanism of general anesthesia in suppressing consciousness. Human cognitive operations take place in hierarchically structured neural organizations in the brain. The process of low-order neural representation of sensory stimuli becoming integrated in high-order cortices is also known as cognitive binding. Combining neuroimaging, cognitive neuroscience, and anesthetic manipulation, we examined how cognitive networks involved in auditory verbal memory are maintained in wakefulness, disrupted in propofol-induced deep sedation, and re-established in recovery. Inspired by the notion of cognitive binding, an functional magnetic resonance imaging-guided connectivity analysis was utilized to assess the

SUBMITTER: Liu X 

PROVIDER: S-EPMC3244539 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature