Chronic multiple sclerosis lesions: characterization with high-field-strength MR imaging.

ABSTRACT:

Purpose

To elucidate the mechanism of magnetic resonance (MR) imaging contrast in multiple sclerosis (MS) lesion appearance by using susceptibility-weighted imaging and to assess with histologic correlation the role of iron and myelin in generating this MR imaging contrast.

Materials and methods

Each patient provided written consent to a human subject protocol approved by an institutional review board. High-spatial-resolution susceptibility-weighted 7.0-T MR images were obtained in 21 patients with MS. Contrast patterns in quantitative phase and R2* images, derived from 7.0-T data, were investigated in 220 areas defined as chronic MS lesions on conventional T2-weighted fluid-attenuated inversion recovery, T2-weighted, and T1-weighted spin-echo images. The presence of positiv

SUBMITTER: Yao B 

PROVIDER: S-EPMC3244667 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature