Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase.

ABSTRACT:

Purpose

To determine if a molecular imaging approach targeting the highly oxidative enzyme myeloperoxidase (MPO) can help noninvasively identify and confirm sites of vascular wall inflammation in a murine model of vasculitis.

Materials and methods

Animal experiments were approved by the institutional animal care committee. Twenty-six mice were studied, including eight MPO-deficient and six sham-operated mice as controls. Vasculitis was induced with intraperitoneal injection of Candida albicans water-soluble fraction (CAWS). Aortic root magnetic resonance imaging was performed after intravenous injection of the activatable MPO sensor (bis-5-hydroxytryptamide-diethylenetriaminepentatacetate gadolinium) (n = 23), referred to as MPO-Gd, or gadopentetate dimeglumine (n = 10). Sev

SUBMITTER: Su HS 

PROVIDER: S-EPMC3244672 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature