Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors.

ABSTRACT: The design, synthesis and biological evaluation of new analogs of the naturally occurring compound cyclopamine, a Hedgehog signaling inhibitor, are described. Stucture-activity relationship studies lead to an evolving model for the pharmacophore of this medically promising compound class of anti-cancer chemotherapeutic agents.

SUBMITTER: Winkler JD 

PROVIDER: S-EPMC3244726 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature