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Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors.

ABSTRACT: The design, synthesis and biological evaluation of new analogs of the naturally occurring compound cyclopamine, a Hedgehog signaling inhibitor, are described. Stucture-activity relationship studies lead to an evolving model for the pharmacophore of this medically promising compound class of anti-cancer chemotherapeutic agents.

SUBMITTER: Winkler JD 

PROVIDER: S-EPMC3244726 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors.

Winkler Jeffrey D JD   Isaacs André K AK   Xiang Chaomei C   Baubet Valérie V   Dahmane Nadia N  

Tetrahedron 20111201 52

The design, synthesis and biological evaluation of new analogs of the naturally occurring compound cyclopamine, a Hedgehog signaling inhibitor, are described. Stucture-activity relationship studies lead to an evolving model for the pharmacophore of this medically promising compound class of anti-cancer chemotherapeutic agents. ...[more]

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