Cerebral infarcts and cognitive performance: importance of location and number of infarcts.

ABSTRACT:

Background and purpose

Cerebral infarcts increase the risk for cognitive impairment. The relevance of location and number of infarcts with respect to cognitive function is less clear.

Methods

We studied the cross-sectional association between number and location of infarcts and cognitive performance in 4030 nondemented participants of the Age Gene/Environment Susceptibility-Reykjavik Study. Composite scores for memory, processing speed, and executive function were created from a neuropsychological battery. Subcortical, cortical, and cerebellar infarcts were identified on brain MRI. We performed linear regression analyses adjusted for demographic and vascular risk factors, depression, white matter lesions, and atrophy.

Results

Compared to participants with no infarcts,

SUBMITTER: Saczynski JS 

PROVIDER: S-EPMC3244834 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature