Role of PECAM-1 in arteriogenesis and specification of preexisting collaterals.

ABSTRACT:

Rationale

Hemodynamic forces caused by the altered blood flow in response to an occlusion lead to the induction of collateral remodeling and arteriogenesis. Previous work showed that platelet endothelial cell adhesion molecule (PECAM)-1 is a component of a mechanosensory complex that mediates endothelial cell responses to shear stress.

Objective

We hypothesized that PECAM-1 plays an important role in arteriogenesis and collateral remodeling.

Methods and results

PECAM-1 knockout (KO) and wild-type littermates underwent femoral artery ligation. Surprisingly, tissue perfusion and collateral-dependent blood flow were significantly increased in the KO mice immediately after surgery. Histology confirmed larger caliber of preexisting collaterals in the KO mice. Additionally,

SUBMITTER: Chen Z 

PROVIDER: S-EPMC3244947 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature