VIRsiRNAdb: a curated database of experimentally validated viral siRNA/shRNA.

ABSTRACT: RNAi technology has been emerging as a potential modality to inhibit viruses during past decade. In literature a few siRNA databases have been reported that focus on targeting human and mammalian genes but experimentally validated viral siRNA databases are lacking. We have developed VIRsiRNAdb, a manually curated database having comprehensive details of 1358 siRNA/shRNA targeting viral genome regions. Further, wherever available, information regarding alternative efficacies of above 300 siRNAs derived from different assays has also been incorporated. Important fields included in the database are siRNA sequence, virus subtype, target genome region, cell type, target object, experimental assay, efficacy, off-target and siRNA matching with reference viral sequences. Database also provides the

SUBMITTER: Thakur N 

PROVIDER: S-EPMC3245049 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature