SitEx: a computer system for analysis of projections of protein functional sites on eukaryotic genes.

ABSTRACT: Search of interrelationships between the structural-functional protein organization and exon structure of encoding gene provides insights into issues concerned with the function, origin and evolution of genes and proteins. The functions of proteins and their domains are defined mostly by functional sites. The relation of the exon-intron structure of the gene to the protein functional sites has been little studied. Development of resources containing data on projections of protein functional sites on eukaryotic genes is needed. We have developed SitEx, a database that contains information on functional site amino acid positions in the exon structure of encoding gene. SitEx is integrated with the BLAST and 3DExonScan programs. BLAST is used for searching sequence similarity between the query

SUBMITTER: Medvedeva I 

PROVIDER: S-EPMC3245165 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature