Restricting microbial exposure in early life negates the immune benefits associated with gut colonization in environments of high microbial diversity.

ABSTRACT:

Background

Acquisition of the intestinal microbiota in early life corresponds with the development of the mucosal immune system. Recent work on caesarean-delivered infants revealed that early microbial composition is influenced by birthing method and environment. Furthermore, we have confirmed that early-life environment strongly influences both the adult gut microbiota and development of the gut immune system. Here, we address the impact of limiting microbial exposure after initial colonization on the development of adult gut immunity.

Methodology/principal findings

Piglets were born in indoor or outdoor rearing units, allowing natural colonization in the immediate period after birth, prior to transfer to high-health status isolators. Strikingly, gut closure and morphologic

SUBMITTER: Mulder IE 

PROVIDER: S-EPMC3245219 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature