Identification of new alleles and the determination of alleles and genotypes frequencies at the CYP2D6 gene in Emiratis.

ABSTRACT: CYP2D6 belongs to the cytochrome P450 superfamily of enzymes and plays an important role in the metabolism of 20-25% of clinically used drugs including antidepressants. It displays inter-individual and inter-ethnic variability in activity ranging from complete absence to excessive activity which causes adverse drug reactions and toxicity or therapy failure even at normal drug doses. This variability is due to genetic polymorphisms which form poor, intermediate, extensive or ultrarapid metaboliser phenotypes. This study aimed to determine CYP2D6 alleles and their frequencies in the United Arab Emirates (UAE) local population. CYP2D6 alleles and genotypes were determined by direct DNA sequencing in 151 Emiratis with the majority being psychiatric patients on antidepressants. Several new alle

SUBMITTER: Qumsieh RY 

PROVIDER: S-EPMC3245235 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature